NuVasive

Adhering to the three core principles of Advanced Materials Science, surface, structure and imaging, NuVasive has pioneered design and manufacturing methods that combine the inherent benefits of porosity with the advantageous material properties of PEEK and titanium, allowing surgeons reliable options for their X360 cases. Learn more about this comprehensive and customizable lateral single-position surgical system at www.nuvasive.com/surgical-solutions/x360/

Advanced screw offering. Locking that enables confidence in your ACDF. Introducing the thinnest plate system on the market,* part of the comprehensive C360 portfolio by NuVasive: https://www.nuvasive.com/c360/ *Data on file. Based on review of publicly available materials at the time of this release. Available in the US only.

The patient has always been at the center of what we do at NuVasive. Our visionchange a patient’s life every minuteis a goal we are committed to achieving. We tapped a handful of our leaders to share our story with you. Hear what they said: https://www.nuvasive.com/

This holiday season we are thankful for our surgeon partners and shareowners for being a bright light this year and for your commitment to transform surgery, advance care and change lives of patients around the globe.

Changing architecture. Changing outcomes. We know that altering the surface and structure of materials with porosity can improve fusion.(1-4) Learn more about our Modulus implants intelligently designed for fusion by going to www.nuvasive.com/modulus/. References 1. Smith WD. Early outcomes of titanium surface textured, 3-dimensional manufactured implants for lumbar spinal fusion. Presented at: SOLAS 11th Annual Meeting; May 17-19, 2018; San Diego, CA, USA. 2. Hill CP and St...renge KB. Early clinical outcomes comparing porous PEEK, smooth PEEK, and structural allograft interbody devices for anterior cervical discectomy and fusion. J Spine Neurosurg 2019;8(1):1-7. 3. Burkus KJ. Early Outcomes of Anterior Cervical Discectomy and Fusion Using a Porous PEEK Interbody Fusion Device. J Spine Neurosurg 2018;7:2. 4. Burkus JK, Rehak C. Anterior Cervical Discectomy and Fusion Using Porous PEEK Implants at Levels Adjacent to a Previous Fusion. J Spine Neurosurg 2019;8:3. Not all products presented here may be available in your market. For specific product offerings available in your country, please contact your local NuVasive representative.

As a company, we are collectively working to create a diverse culture where everyone is included and valued for who they are. Weaving a culture of diversity and inclusion into everything we do will continue to reinforce our commitment to transform surgery, advance care, and change lives. In our new series, Cheetah Chats with Diversity + Inclusion, we will elevate the voices and stories of our own Shareowners to reflect on where we've been and where we plan to go with our D+I efforts. Hear from Aliah about her career development through opportunities with our employee resource group, Women in Spine:

While this year tested and challenged us like no other, we were also presented with a number of opportunities to adapt, learn, and grow. Despite a virtual setting, our employee resource group, Women in Spine (WIS), found new ways to keep Shareowners engaged and connected by providing development webinars, access to leadership, community events and open-dialogue sessions. Read more for some of the top WIS highlights of this year: https://www.nuvasive.com/women-in-spine-2020-highlights/

In this featured case, Dr. Aaron J. Buckland and Dr. Juan C. Rodriguez-Olaverri perform a T4-L3 open correction with Reline 3D and NuVasive Power Final Tightening on a patient suffering from idiopathic scoliosis and 55 1AR curve. Click below to read the latest feature:

Now more than ever, companies are finding unique ways to keep their employees connected and engaged virtually. With in-person group celebrations postponed for the time being, we recently got creative by celebrating the changing season with a virtual Fall Festival! Read more about the festivities in our latest blog: https://www.nuvasive.com/nuvasive-fall-festival-recap/

The new ACP is procedurally integrated with versatile instrumentation, a complete interbody portfolio featuring advanced porous materials, traditional PEEK and allograft, biologics, the Maxcess C retractor and enabling technologies. Learn how the thinnest plate system on the market* is part of the comprehensive C360 portfolio: visit https://www.nuvasive.com/c360/ *Data on file. Based on review of publicly available materials at the time of this release.

Hear from Dr. Rick Sasso from the Indiana Spine Group hospital on the upcoming, reimagined ACDF procedural solution. Featuring an ultra-thin plating system supported by a complete interbody portfolio, watch below. Want more? Drs. Rick Sasso, Chris Shaffrey and Reg Haid discuss the need to change anterior cervical surgery here: https://www.youtube.com/watch

The Better Way Back (TBWB) is a NuVasive program that is committed to raising public awareness for spine disorders and educating patients, loved ones, clinicians, and healthcare providers about treatment options, including surgery. In this new series, you will hear from some of our own TBWB patient ambassadors who are dedicated to sharing their stories of challenge and hope. In this patient story, you'll learn more about Chris, a patient who underwent an XLIF corpectomy at L4-L5 with Dr. Dave Seecharan: https://www.nuvasive.com/tbwb_patient_success_story_chris/ Each individual’s surgical procedure and recovery may deviate from what is described herein. This information is not intended to supersede or supplant the information provided by your doctor.

Next week, we will be hosting Unida, a two-part program bringing awareness and recognition for the Hispanic community to both Shareowners and college students affiliated with the Society of Hispanic Professional Engineers. Our featured presenter and surgeon partner, Dr. Juan Uribe, reflected on his Hispanic identity and what it means to be a Hispanic leader and innovator in the medical field. Here what he said below:

In this debate, Dr. Patrick Sugrue and Dr. Yashar Javidan discuss the use of VersaTie for supplemental fixation, translation in complex neuromuscular pediatric patients as well as exploring the additional uses of VersaTie in their practices. Watch the full debate here: https://youtu.be/2o2wsEQUuyM

The NuVasive Sales Training program has played an instrumental role in the training of our commercial teams since NuVasive developed the XLIF procedure. Read more in our latest blog on how the Sales training team had to quickly pivot from their once hands-on training experience to a virtual format back in March: https://www.nuvasive.com/nuvasive-sales-training-goes-virt/

In celebration of National Hispanic Heritage Month, we asked our Shareowners how they feel their Hispanic/Latinx identities have shaped who they are today. Later this month, we'll be hosting Unida, a two-part program bringing awareness and recognition about the Hispanic community to both Shareowners and college students affiliated with the Society of Hispanic Professional Engineers (SHPE). Stay tuned for more event details!

Hear from Dr. Bae, Dr. Cheng, Dr. Inkrott and Dr. Summa on how they manage hospital costs while utilizing less invasive techniques. From efficiencies in the operating room and less PPE usage, to operating in ambulatory surgery centers, learn how LIS surgery has impacted their practices and health systems. Spine surgery evolved. Learn more about the NuVasive less invasive procedural solutions by clicking here: https://youtu.be/N7X-wQ579Xk

In this comparative clinical study featuring Drs. Clint P. Hill and K. Brandon Strenge, porous PEEK implants demonstrated greater improvements in early clinical outcomes compared to smooth PEEK and structural allograft. Read our latest blog to learn more: https://www.nuvasive.com/ams-clinical-study-spotlight/ 1. Hill CP, Strenge KB (2019) Early Clinical Outcomes Comparing Porous PEEK, Smooth PEEK, and Structural Allograft Interbody Devices for Anterior Cervical Discectomy and Fusion. J Spine Neurosurg 8:1.

Listen in as Dr. Kenneth Burkus discusses the current state of ceramic bone graft substitutes and implants, porous surface technologies that help promote bone fusion, and demonstrated usage and benefits of advanced surface technologies. Watch the full webinar here: https://youtu.be/LMKRh1kQH98

LIS surgeons are enabling up to 90% reduction in patient blood loss,(1-4) and you could be too. Less invasive surgery is your opportunity to change the way patient care is delivered. The intuitive approach, paired with best-in-class training and a robust procedural portfolio, enables you to confidently adopt less invasive techniques to achieve the same or better outcomes. It’s time to evolve. #spinesurgeryevolved2020 References: ... 1. Dakwar E, Cardona RF, Smith DA, et al. Early outcomes and safety of the minimally invasive, lateral retroperitoneal transpsoas approach for adult degenerative scoliosis. Neurosurg Focus 2010;28(3):E8. 2. Lehmen JA, Gerber EJ. MIS lateral spine surgery: a systematic literature review of complications, outcomes, and economics. Eur Spine J 2015;24(Suppl 3):S287-313. 3. Dhall SS, Wang MY, Mummaneni PV. Clinical and radiographic comparison of mini-open transforaminal lumbar interbody fusion with open transforaminal lumbar interbody fusion in 42 patients with long-term follow-up. J Neurosurg Spine 2008;9(6):560-5. 4. Whitecloud TS, Roesch WW, Ricciardi JE. Transforaminal interbody fusion versus anterior-posterior interbody fusion of the lumbar spine: a financial analysis. J Spinal Disord 2001;14(2):100-3.

Recently, Shareowners had the honor of tuning into a virtual webinar presentation from award-winning motivational speaker, Ritu Bhasin, hosted by Women In Spine. The webinarAuthenticity in the workplacegave Shareowners the opportunity to learn more about how to embrace authenticity in their professional and personal lives. Read more about it in our latest blog: https://www.nuvasive.com/wis_authenticity_in_the_workplace/

Hear from Dr. Bae, Dr. Belanger, Dr. Summa, and Dr. Uribe on how on they talk to patients about less invasive surgery. Learn about the resources and programs that are available for patients and how they are leveraging telemedicine in the current environment. Spine surgery evolved. Learn more about the NuVasive less invasive procedural solutions here: https://youtu.be/BC__tNp4HMU

LIS surgeons are enabling shorter recovery times, and you could be too. With 97% fusion/healing rates,(3) XLIF is the only lateral spinal fusion procedure to be clinically validated with over 350 peer-reviewed articles. It’s time to evolve. Learn more by going to: https://www.nuvasive.com/less-invasive-surgery/ References: 1. Ozgur BM, Agarwal V, Nail E, et al. Two-year clinical and radiographic success of minimally invasive lateral transpsoas approach for the treatment of d...egenerative lumbar conditions. SAS J 2010;4:416. 2. Park Y, Ha JW. Comparison of one-level posterior lumbar interbody fusion performed with a minimally invasive approach or a traditional open approach. Spine 2007;32(5):537-43. 3. Rodgers WB, Gerber EJ, Patterson JR. Fusion after minimally disruptive anterior lumbar interbody fusion: analysis of extreme lateral interbody fusion by computed tomography. SAS Journal 2010;4:63-6. See more

Changing architecture. Changing outcomes. Learn more about Porous PEEK by visiting www.nuvasive.com/surgical-sol/advanced-materials-science//